4-Nitrophenyl 3-(Benzo[d][1,3]dioxol-5-yl)-2-methylpropanoate is a chirally defined, pre-activated acylating agent that combines a metabolically stable benzo[1,3]dioxole (piperonyl) pharmacophore with the exceptional reactivity of a 4-nitrophenyl ester. It enables the efficient, racemization-free introduction of a complex, chiral acid moiety under mild conditions, making it invaluable for advanced synthetic and bioconjugation chemistry.
4-Nitrophenyl 3-(Benzo[d][1,3]dioxol-5-yl)-2-methylpropanoate is a specialty ester designed as a reactive biochemical or synthetic intermediate. Its structure strategically combines three key units:
(1)A 3-(benzo[1,3]dioxol-5-yl)-2-methylpropanoic acid (piperonyl-substituted, chiral acid) moiety.
(2)A 4-nitrophenyl ester leaving group.
This design makes it an activated ester, where the 4-nitrophenol is an excellent leaving group, facilitating efficient acyl transfer reactions under mild conditions.
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